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A paradoxical synergistic effect between Resveratrol and copper (II) with respect to degradation of DNA and RNA


Since our study shows that Cfs are DNA damaging agents with implications for diseases associated with elevated Cfs levels, removal / degradation of Cfs could be of therapeutic value. Resveratrol (R), a plant polyphenol, is known to reduce Cu (II) to Cu (I) generating reactive oxygen species that can cleave plasmid DNA. We have observed that there exists a synergistic effect between R and Cu whereby plasmid DNA cleaving / degrading activity of R-Cu progressively increases as the ratio of R to Cu is increased i.e., the concentration of Cu is successively reduced with respect to a fixed concentration R. Whereas cleavage of DNA occurs at low molar ratios of R to Cu, at higher ratios, complete degradation of DNA is achieved. With further increases in the ratio, wherein the concentration of Cu is reduced to very low levels, the DNA degrading activity of R-Cu is gradually lost. This synergistic effect is also seen with respect to eukaryotic genomic DNA and RNA. This data indicate that R-Cu may have potential in vivoCfs degrading activity and suggest that it might be possible to reduce the concentration of Cu to our advantage so as to obviate any toxic side-effects of Cu.

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