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Research Projects

Omics approach to elucidate the molecular mechanisms of Glioblastoma resistance


Cellular signalling is complex network of many signalling pathways coordinating together. To get a comprehensive understanding of dynamic pathway networks operative in resistant cancer cells, we are analyzing total transcriptome and proteome of these cells by using RNA seq (transcriptome) and iTRAQ (proteomic). This combined experimental approach and comparison with therapy sensitive cancer cells will provide quantitative data that can help us in identifying key molecular pathway networks responsible for the disease state and therapy resistance.

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