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Principal Investigator

Dr. Sanjay Gupta

Dr. Sanjay Gupta

Principal Investigator

Honors and Recognitions

Recognized PhD Mentor for

  • Life Sciences of the Homi Bhabha National Institute
  • Biochemistry of the Mumbai University
  • Epigenetics and Cancer of Manipal Academy of Higher Education

Research Interests

Epigenetics, Chromatin, DNA methylation, Transcriptional regulation and Molecular Carcinogenesis


Histone proteins and their site-specific post-translational modifications regulate process like gene expression, DNA repair, and therefore emerging as key players in cancer and the resistance mechanisms. Recent advances from the group strongly indicate a role for histone, HIST2H2AC and H3.2, and also the part of 3’-UTR organization of histone genes for the genomic instability in human liver, gastric and breast cancers. Further, the critical role of chromatin modifiers like mitogen and stress activated kinase 1, protein phosphatase 1 and class 1 histone deacetylase for H3serine10phosphorylation along with site-specific acetylation in DNA damage response have been identified in human cell lines and gastric cancer tissues. Recent studies have shown reversible mechanism of resistance is mediated by changes in chromatin organization. These epigenetic regulators have significant clinical importance as they provide an opportunity for “epi-drugs” to reverse the specific marks for better management of cancer and resistance phenomena.

Histome2 Database

Theme 1: Histone variants and isoforms in cancer and development

Theme 2: DNA Damage Repair and Resistance Mechanisms in Cancer

Theme 3: Histone post translational modification and their therapeutic potential in Cancer

Ongoing Research Projects

  • Histone Alterations and DNA Damage

    Histone Alterations and DNA Damage

    Previous studies in different models from yeast to human cells imply that chromatin structure serves as a barrie… more

  • Histone PTM's and Cancer

    Histone PTM's and Cancer

    Epigenetic changes like histone post translational modifications and change in chromatin architecture are key ev… more

  • Histone Variants and Cancer

    Histone Variants and Cancer

    Histones are very highly conserved proteins and packaging the genome was the primary function previously associa… more

  • Histone Biogenesis and Cancer

    Histone Biogenesis and Cancer

    The chromatin state is known to be influenced by multiple mechanisms, including changes in the histone PTMs, inc… more

Lab Members

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Office Contact

Dr. Sanjay Gupta

KS#313, Gupta Lab, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5086

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