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Research Projects

Understanding replication stress and its implication in resistance to radiation therapy


Functional characterization of a novel cancer associated gene named BRCA2 and CDKN1A Interacting Protein (BCCIP) in stabilization of stalled replication forks using mammalian cell cultures and Drosophila melanogaster as model systems. BCCIP is involved in homologous-recombination (HR) mediated DNA repair. We are investigating if similar to other HR proteins, BCCIP also has mechanistically different functions during replication- stress response which remain poorly understood. This study focuses towards understanding the cellular responses to replication stress and their implications in tumorigenesis as well as resistance to radiation therapy.

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