Inner Banner

Principal Investigator


Dr. Ashok K Varma

Principal Investigator

Research Interests

  • Structural determination of different functional domains of BRCA1/2, MAPK, PML-RARA
  • Genomics of Hereditary Breast and Ovarian Cancer
  • Proteomics of Head and neck squamous cell carcinomas (HNSCC)
  • Urine proteomics of Bladder cancer
  • National Cancer Database for Translational Research


The lab focuses on the X-ray structure determination of biological macromolecules: proteins - nucleic acid interactions. Pathogenicity of mutations identified from larger cohort of Hereditary Breast and Ovarian Cancer patients.   Proteomics based approach to predict early detection biomarker using serum and urine.

Ongoing Research Projects

  • image1

    Structural based evaluation of pathogenicity mutations identified in BRCA1/2 (Brea…

  • image2

    FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex

  • image2

    Structural and functional analysis of RAS-RAF-MEK-ERK-RSK Pathways to regulates…

  • image3

    Structural and functional basis to evaluate different functional domains of PML-RA…

  • image4

    Proteomics studies of a set of predictive and prognostic protein biomarkers in hea…

  • image5

    Proteomics based approach to evaluate the urinary biomarkers for bladder cancer tr…

Lab Members




Office Contact

Dr. Ashok K Varma

KS 101, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5112
Back to Top