Principal Investigator

Dr. Ashok K Varma

Research Interests

Histone Biology and Cellular Plasticity
Chromatin Dynamics and DNA damage response
Epigenetics and Transcriptional Regulation
Chromatin Modifications and Resistance Mechanisms

RESEARCH

The lab will focus on the X-ray structure determination of biological macromolecules: proteins - nucleic acid. This detailed 3D visualization of proteins will brings to Structure Based Drug Design – Molecular Medicine- Treatment of Disease.

Ongoing Research Projects

BRCA1(Breast Cancer Associated Domain-1):Three dimensional structural characteriza…
IKBKE(I-kappa-B kinase epsilon)-Structural mechanism to understand IKBKE as a pote…
FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex
ERK1/2-SmaV: Phospho ERK1/2 binding analysis with SmaV and structural characteriza…
Human a3 (IV) NC1: structural and binding analysis to integrin receptors Collabora…
CHK1/2 (Checkpoint kinase 1/2): Structural integrity of CHK1/2 in tumorigenesis
MDC1 ( Mediator of DNA damage checkpoint protein 1): Structural and binding anal…
EPH-B2:Cell signaling and biophysical interaction analysis with ephrin Receptor Co…

Lab Members

Siddhartha Barua
Senior Research Fellow
Siddhartha Barua
Senior Research Fellow
Shubhashish Chakraborty
Senior Research Fellow
Shubhashish Chakraborty
Senior Research Fellow
Vaishnvee Chikhale
Senior Research Fellow
Vaishnvee Chikhale
Senior Research Fellow
R N Sawant
Technician
R N Sawant
Technician
Suchita Dubey
Senior Research Fellow
Suchita Dubey
Senior Research Fellow
Mrs. Arpita. M. Mhatre
Administrative Assistant
Mrs. Arpita. M. Mhatre
Administrative Assistant
Mr. Gokul Arora
Junior Research Fellow
Mr. Gokul Arora
Junior Research Fellow
Mr. Aman Jaiswal
Junior Research Fellow
Mr. Aman Jaiswal
Junior Research Fellow
Ulka U Sawant
Scientific Assistant
Ulka U Sawant
Scientific Assistant
Neha Mishra
Senior Research Fellow
Neha Mishra
Senior Research Fellow

Alumni

PUBLICATIONS

2023
Structural dynamics of clinically-reported VUS in the BARD1 ARD-BRCT region to predict the molecular basis of alterations. Journal of Biomolecular Structure and Dynamics.
Barua SA, Choudhary RK, Gawde J, Mishra N, Varma AK
Evaluation of pathogenicity and structural alterations for the mutations identified in the conserved region of the C‑terminal kinase domain of Human-Ribosomal S6 Kinase 1. ACS Omega.
Chikhale V, Goswami N, Khan MA, Borah P, Varma AK.
2022
In Silico and Structure-Based Assessment of Similar Variants Discovered in Tandem Repeats of BRCT Domains of BRCA1 and BARD1 To Characterize the Folding Pattern, ACS Omega DOI: 10.1021/acsomega.2c04782
Siddhartha A. Barua, Nabajyoti Goswami, Neha Mishra, Ulka U. Sawant, and Ashok K. Varma
Breast Cancer Is Significantly Associated with Cancers in The First- and Second-Degree Relatives in Ethnic Mizo-Mongoloid Population, Northeast India; Natl J Community Med 2022;13(9):606-611
Doris Zodinpuii, Jeremy L Pautu, Bawitlung Zothankima, Lalfakzuala Khenglawt, Doris Lallawmzuali, Rebecca Lalmuanpuii, Lalfak zuali, Lalengkimi Ralte, Rajendra B Muthukumaran, Ashok K Varma, John Zothanzama, Nachimuthu Senthil Kumar

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Contact

Office Contact

Dr. Ashok K Varma

KS 101, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5112 avarma@actrec.gov.in

Principal Investigator

Dr. Ashok K Varma

Research Interests

RESEARCH

Ongoing Research Projects

BRCA1(Breast Cancer Associated Domain-1):Three dimensional structural characteriza…

IKBKE(I-kappa-B kinase epsilon)-Structural mechanism to understand IKBKE as a pote…

FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex

ERK1/2-SmaV: Phospho ERK1/2 binding analysis with SmaV and structural characteriza…

Human a3 (IV) NC1: structural and binding analysis to integrin receptors Collabora…

CHK1/2 (Checkpoint kinase 1/2): Structural integrity of CHK1/2 in tumorigenesis

MDC1 ( Mediator of DNA damage checkpoint protein 1): Structural and binding anal…

EPH-B2:Cell signaling and biophysical interaction analysis with ephrin Receptor Co…

Lab Members

Alumni

Dr. Vikrant

Dr. Rajan kumar choudhary

Dr. Bhanu Jagilinki

Dr. M. Quadir Siddiqui

Dr. Mudassar Ali Khan

Dr. Lumbini Yadav

Lipi Das

Dr. dilip.badgujar

PUBLICATIONS

Contact

Office Contact

Dr. Ashok K Varma

For Research Scientist

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Societies

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