Acute Myeloid Leukemia (AML) is a type of blood cancer. Even though patients get the same treatment, some get cured whereas others relapse. The reason is that AML is a biologically heterogeneous cancer. Some patients of AML have chromosomal abnormalities in their leukemic cells whereas others have mutations in genes or in some cases there is a combination of both. These genetic changes harbored by the leukemic cells are critical in influencing response to treatment and disease outcome.