is funded by the Department of Science and Technology, Government of India. Triple Negative Breast Cancer (TNBC) is a type of breast cancer characterized by the lack of expression of hormone receptors. TNBC is an aggressive breast cancer, very often irresponsive to treatment. Moreover, TNBC has more propensity to metastasize to other organs.

funded by the Tata Memorial Centre explores the role of peri-operative hypoxia in breast cancer biology. Hypoxia is a consistent feature of most solid tumours with variable incidence and severity. Chronic hypoxia has been well studied and characterized. However, the role of acute hypoxia, especially in the peri-operative setting wherein ligation of blood vessels leads to acute hypoxia in surgically resected tissue, requires elucidation.

The proluton study aimed to identify the molecular mediators of beneficiary survival effect of a single depot hydroxyl-progesterone dose in node positive patients eligible for upfront surgical resection (PMID: 21670457). We subjected patient samples before, and after, hydroxyl-progesterone peri-operative intervention, to whole transcriptome sequencing on a next generation sequencing platform.