Inner Banner

Research Projects

Investigating therapeutic potential of PIK3CA inhibitors for ovarian cancer carrying oncogenic mutant p53

Investigating therapeutic potential of PIK3CA inhibitors for ovarian cancer carrying oncogenic mutant p53

Wild-type p53, a tumour suppressor, has been reported to downregulate PIK3CA expression in ovarian cancer. Molecular profiling of HGSOC showed alterations in pro-survival, PI3K/AKT pathways genes in 34% of cases along with an overwhelming presence of p53 mutations (>96%). My work involves studying the association of oncogenic mutant p53 with the PIK3CA/AKT signalling pathway in HGSOC and test the efficacy of PIK3CA inhibitors on cells expressing mutant p53 as well as on patient derived primary cells.

Usha Patel

Senior Research Fellow

Megha Mehrotra

Back to Top The website encountered an unexpected error. Please try again later.