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Principal Investigator

Dr. Rajiv Sarin

Principal Investigator

RESEARCH

The research programme of the Cancer Genetics Unit has evolved over a decade from a clinical genetics programme to the present comprehensive programme including molecular genetics initiated after establishing the SARIN Lab in 2007 and now moving to population genetics. Several thousand subjects from ~1000 families with various hereditary cancer syndromes have been registered and a Bank of their Genomic DNA and EBV transformed lymphoblastoid cell line established. In addition there is a cohort of cases and controls with Multiple Primary Neoplasm (MPNs) and sporadic breast, thyroid or early age cancers with their genomic DNA banked.Biobanking of various tumour tissues with full clinical annotation has also been initiated. Utilizing these resources and collaborators, research has been initiated to examine 3 major aspects of cancer genetics:

Ongoing Research Projects

  • project1

    Genetic Predisposition from High Penetrance Genes modulating factors in Hereditary…

    The mutation spectra in ethnic Indian families with diverse hereditary cancer syndromes has been identified and… more

  • project1

    Genetic predisposition to cancer from Low Penetrance Genes & their Interaction…

    Breast Cancer – BRCAGEL Case Control Study : evaluating 25 SNPs and various reproductive, lifestyle, dietary, ch… more

  • project1

    Genetic alterations in Step-wise carcinogenesis model

    Established a major programme under International Cancer Genome Consortium – India projectwhere high quality ann… more

  • project1

    International Cancer Genome Consortium

    This international collaborative project aims to establish a comprehensive catalogue of Genomic & other abno… more

  • project1

    Centre for Advanced Research for Cancer Genetics and Genomics

    It is now the Apex National Referral Centre for comprehensive clinical and laboratory genetic services and genet… more

  • project1

    Breast Cancer Genetic,Environment and lifestyle Study in Familial & Non Famili…

    Collaborative study with Prof Hebert, nutritional epidemiologist-(Univ. South Carolina) & leading Indian can… more

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. Rajiv Sarin

Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000Lab Website

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