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Principal Investigator

Milind

Dr. Milind Vaidya

Principal Investigator and Scientific Officer"G"

Honors and Recognitions

Invited speaker at Gorden conference on Intermediate filaments (2010, 2012), Executive committee member for Indian Society of Cell Biology 2013-15.

Research Interests

Epigenetics, Chromatin, DNA methylation, Transcriptional regulation and Molecular Carcinogenesis, Keratins, Vimentin, IF associated proteins, Biomarkers

RESEARCH

"The lab is on understanding functions of IF proteins an IF associated proteins in cell transformation/differentiation and their use as biomarkers. They have been working on developing keratins as specific markers for diagnosis and prognosis of human cancer and potentially malignant lesions. They are also exploring the possibility of using a battery of biomarkers which include Keratin associated proteins for prognostication of cancer. Investigating the use of serum Keratin fragments as noninvasive prognostic markers for oral cancer. Studies related to possible role of Vimentin, K8/18 and their post translational modifications in governing processes like cell differentiation, transformation and apoptosis have been initiated. Our other interest includes development of chemical and transgenic models to study the process of oral carcinogenesis"

Ongoing Research Projects

  • project1

    Global profiling of proteins in experimental rat buccal mucosal and lingual carcin…

  • project1

    Prognostic value of tissue polypeptide antigen in oral squamous cell carcinoma

  • project1

    Use of cytokeratins as prognostic markers in human oral precancer and cancer

  • project1

    Role of aberrant vimentin expression in human oral pre-cancer and cancer

  • project1

    Role of Keratin 8 phosphorylation in neoplastic progression of squamous cell carci…

  • project1

    The role of hemidesmosomal linker proteins in neoplastic progression of squamous c…

  • project1

    Role of Keratins 8, 18 and Vimentin during epithelial mesenchymal transition (EMT)…

  • project1

    Enrichment and characterization of cancer stem like cells: Applications in oral ca…

  • project1

    Depicting the mechanism of K5 and K14 regulated cell proliferation/differentiation…

  • project1

    Changes in keratin expression, localization and their interaction with membrane pr…

  • project1

    Keratins 8 and 18 associated neoplastic progression through integrin mediated sign…

  • project1

    Role of Fascin in progression of oral squamous cell carcinoma

  • project1

    Effect of loss of K8 phosphorylation in oral squamous cell carcinoma

  • project1

    Role of K5/14 in proliferation and differentiation

  • project1

    Role of cytokeratin 8 and 18 in differentiation and transformation of epithelial c…

Lab Members

PUBLICATIONS

  • 2014
    Clinicopathological features and prognostic implications of loss of K5 and gain of K1, K8 and K18 inoral potentially malignant lesions and squamous cell carcinomas: Immunohistochemical analysis. Online published in the Journal of Tumor Biology

    Lalit Sehgal, Amitabha Mukhopadhyay, Anandi Rajan, Nileema Khapare, Mugdha Suresh Sawant, Sonali S Vishal, Khyati Bhatt, Srikant Ambatipudi, Noelle Antao, Hunain Alam, Mansa Gurjar, Srikanta Basu, Rohit Mathur, Lalit Borde, Amol S Hosing, Milind M Vaidya,

    14-3-3&[gamma] meditated transport of plakoglobin to the cellborder is required for the initiation of desmosome assembly in vitro and invivo. Journal of Cell Science

    Lalit Sehgal, Amitabha Mukhopadhyay, Anandi Rajan, Nileema Khapare, Mugdha Suresh Sawant, Sonali S Vishal, Khyati Bhatt, Srikant Ambatipudi, Noelle Antao, Hunain Alam, Mansa Gurjar, Srikanta Basu, Rohit Mathur, Lalit Borde, Amol S Hosing, Milind M Vaidya,

    Quantitative proteomic analysis of different stages of rat lingual carcinogenesis

    Bihari Lal Soni, Arivusudar Marimuthu, Harsh Pawar, Sharada S Sawant, Anita Borges, Ranganathan Kannan, Akhilesh Pandey, Arvind D Ingle, Hindahally Chandregowda Harsha, Milind Murlidhar Vaidya.

  • 2013
    Quantitative proteomic analysis of different stages of rat lingual carcinogenesis Clin Commun Oncol 2014, 1:2 (9 May 2014) DOI:10.4103/WKMP-0062.132172

    Sharada S. Sawant, Milind M. Vaidya, Devendra A. Chaukar, Hunain Alam, Crismita Dmello, Prakash Gangadaran, Sadhana Kannan, Shubhada Kane, Prerana P. Dange, Nigamananda Dey, Ranganathan K, Animal K. D’Cruz 

Contact

Office Contact

Dr. Milind Vaidya

Khanolkar Shodhika, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) Tata Memorial Centre Kharghar, Navi Mumbai - 410 210+91-22-2740 5055 mvaidya[at]actrec[dot]gov[dot]in

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