PI Publications
- 2025Development of bitopic nanobody-ligand conjugates targeting G protein-coupled receptors and exhibiting logic-gated signaling. PLOS Biology 23(11):e3003424
Sachdev S, Roy S, Cheloha RW (2025)
Evaluation of AlphaFold modeling for elucidation of nanobody-peptide epitope interactions. Journal of Biological Chemistry. 301(7):110268Sachdev S, Roy S, Saha SJ, Zhao G, Kumariya R, Creemer BA, Yin R, Pierce BG, Bewley CA, Cheloha RW (2025)
- 2024Highly biased agonism for G protein-coupled receptor ligands via nanobody tethering. Nature Communications. 15:4687
Sachdev S, Creemer BA, Gardella TJ, Cheloha RW (2024)
- 2022Rapid covalent labeling of membrane proteins on living cells using a nanobody-epitope tag pair. Bioconjugate Chemistry. 33(10):1867–1875
Cabalteja CC, Sachdev S, Cheloha RW
Characterization of a nanobody-epitope tag interaction and its application for receptor engineering. ACS Chemical Biology 17(8):2296–2303Cabalteja CC, Sachdev S, Cheloha RW
Quantifying the kinetics of signaling and arrestin recruitment by nervous system G protein-coupled receptors. Frontiers in Cellular Neuroscience. 15:814547Hoare SRJ, Tewson PH, Sachdev S, Connor M, Hughes TE, Quinn AM
- 2021Strategies for targeting cell surface proteins using multivalent conjugates and chemical biology. Methods in Cell Biology. 166:205–222
Sachdev S, Cabalteja CC, Cheloha RW
- 2020Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists. Pharmacology Research & Perspectives. 8(2):e00566
Sachdev S, Banister SD, Santiago M, Bladen C, Kassiou M, Connor M
Evaluating opioid-mediated adenylyl cyclase inhibition in live cells using a BRET-based assay. Methods in Molecular Biology. 117–125Manandhar P, Sachdev S, Santiago M
- 2019In vitro determination of the efficacy of illicit synthetic cannabinoids at cannabinoid receptor 1. British Journal of Pharmacology. 176(24):4653–4665
Sachdev S, Vemuri K, Banister SD, Longworth M, Kassiou M, Santiago MJ, Makriyannis A, Connor M
Absence of entourage: terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human cannabinoid receptor 1 and cannabinoid receptor 2. Cannabis and Cannabinoid Research. 4(3):165–176Santiago M, Sachdev S, Arnold JC, McGregor IS, Connor M
- 2016The pharmacology of valinate and tert-leucinate synthetic cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and their analogues. ACS Chemical Neuroscience. 7(9):1241–1254
Banister SD, Longworth M, Kevin RC, Sachdev S, Santiago M, Stuart J, Mack JBC, Glass M, McGregor IS, Connor M, Kassiou M (2016).