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Principal Investigator

Dr. Kakoli Bose

Principal Investigator

Honors and Recognitions

  • Recipient of National Women Bioscientist Award, Govt. of India, 2015 (Young Category)
  • Editorial Board Member, Biochem. J, Portland Press, UK.

Research Interests

  • Biophysics, Biochemistry, Structural Biology, ChemicalBiology, Cell Biology, Enzymology and Computational Biology
  • Research focused on macromolecules involved in alternate pathways of apoptosis and their associated diseases

RESEARCH

Highlights of the research findings at Bose Lab include elucidation of the structural basis of HtrA2 mutations that are implicated in diseased phenotypes. Crystallography data of one such mutants has been deposited in Protein Data Bank (PDB ID: 5WYN). The laboratory has made several important discoveries such as mode of interaction of HtrA2 with its natural substrate, identification of a novel binding partner as well as design of its promising inhibitors. These crucial pieces of information would provide means to manipulate HtrA2 with desired characteristics. The laboratory has developed a database comprising PDZ-domain containing proteins ‘PDZscape’, which is freely available to the users worldwide.

Ongoing Research Projects

  • project1

    Identification & Characterization of Novel Binding Partner of Serine Protease…

    The project involves understanding allosteric behavior of a proapoptotic serine protease HtrA2 so as to establis… more

  • project2

    Investigating the molecular basis of CaM/c-FLIP interaction to design specific c-F…

    With the information that Fas-mediated apoptosis and tumorigenesis are influenced by CaM/c-FLIP With the informa… more

  • project3

    Understanding the basis of Interaction between proapoptotic serine protease HtrA2/…

    This project aims at elucidating GRIM-19-mediated allosteric activation of HtrA2 with an aim at designingThis pr… more

  • project4

    Design and characterization of specific modulator for pro-apoptotic serine proteas…

    This project concerns design, synthesis & profiling of specific HtrA2/Omi inhibitor that might be useful for… more

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. Kakoli Bose

Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India. +91 (022) 2740 5000/ 6873 5000 Extn-5109 kbose@actrec.gov.in Lab Website

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