The focus of our group is to unravel the molecular and cellular mechanisms involved in the developmental signaling such as Wnt/Notch/Sonic hedgehog etc., and metabolic pathways that regulate the self-renewal and differentiation of adult stem cells and cancer stem-like cells including its therapy resistance to epithelial cancer. We are using transgenic animal skin epithelia model, head and neck cancer, and also have developed patient-derived oral cancer cell lines, to identify the genes involved in signaling pathway and metabolic switch that imparts resistance to cancer stem cells thereby providing avenues for therapeutic intervention.
Enhancing factor (EF), a growth factor modulator, is the mouse homologue of human secretory group II phospholipa… more
Signaling pathways such as Wnt/Notch/Sonic hedgehog regulate stem-cell renewal, and genes affected in these path… more
Breast cancer is classified into four subtypes in clinic as ER+ (luminal A or luminal B, usually PR+/− Her2−),ov… more
"Head and neck squamous cell carcinoma (HNSCC) ranks sixth worldwide for cancer-related mortality. Research in c… more
Mehta D, Roy S, Joshi P, Parab M, Waghmare S
Waghmare M, Qureshi T, CM Krishna, Pansare K, Gadewal N, Hole A, Dongre P
Sunkara RR, Mehta D, Sarate RM, Waghmare SK