Principal Investigator
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- Dr. Gunjan Mandal
Dr. Gunjan Mandal
Principal Investigator
Honors and Recognitions
- 2024 - Awarded ICMR-initiated Small Research Grant
- 2023 - Awarded ANRF-funded Startup Research Grant
- 2022 - Travel award to attend American Association for Immunologists conference, Portland, USA
- 2016 - Travel award to attend the second ESMO Asia Congress, held in Singapore
- 2016 - Research Eligibility Test, Department of Zoology, University of Calcutta, Kolkata, India
- 2015 - Best poster presenter in Immunocon 2015, RMRIMS, Patna, India
- 2015 - DST-funded Research exchange visit to Rhodes University, Grahamstown, South Africa
- 2015 – CSIR-UGC NET for PhD Research Fellowship
- 2014 - Best poster presenter in Immunocon 2014, Madurai Kamaraj University, Madurai, India
- 2013 - Manju Biswas Award, Department of Zoology, University of Calcutta
- 2012 - CSIR-NET (Life Sciences) for PhD Research Fellowship
Research Interests
- The comprehensive mechanism of intratumoral germinal center formation
- How the effectiveness of antibodies produced by tumor-infiltrating B cell is determined by the tumor microenvironment and conventional therapies such as radiotherapy and chemotherapy
- Developing novel vaccines strategies for these cancers
- Developing off-the-shelf engineered CAR products with reduced GvHD risks.
RESEARCH
Solid tumor malignancies are often infiltrated with prognostically relevant immune cells that include myeloid cells, lymphocytes, and NK cells. The multicellular complex interactions between immune cells and non-immune cells in the tumor microenvironment determine sustained robust effective antitumor immune response. It is evident that a coordinated humoral response with cellular arm of adaptive immunity develops robust and sustained effectiveness and long-term memory associated with immune protection against multiple cancers. The crosstalk of B lymphocytes with other immune cells at tumor beds is an area of strong interest. We speculate that a broader cellular network along with immune and non-immune cells work synergistically to form intratumoral germinal center providing strong antibody driven protection against epithelial malignancies. The insights will aid in next generation cellular therapies to target solid tumors effectively. The lab research focuses primarily in women: breast cancer, ovarian cancer and endometrial cancer.
Interested about joining Gunjan Lab group– send email to gunjan.mandal[at]actrec[dot]gov[dot]in Wish to request for sharing research materials– send email to gunjan.lab[at]actrec[dot]gov[dot]in or truptininadpradhan5[at]gmail[dot]com For official communication please email to: gunjan.mandal[at]actrec[dot]gov[dot]in
