Principal Investigator

Dr. Ashok K Varma

Research Interests

Histone Biology and Cellular Plasticity
Chromatin Dynamics and DNA damage response
Epigenetics and Transcriptional Regulation
Chromatin Modifications and Resistance Mechanisms

RESEARCH

The lab will focus on the X-ray structure determination of biological macromolecules: proteins - nucleic acid. This detailed 3D visualization of proteins will brings to Structure Based Drug Design – Molecular Medicine- Treatment of Disease.

Ongoing Research Projects

BRCA1(Breast Cancer Associated Domain-1):Three dimensional structural characteriza…
IKBKE(I-kappa-B kinase epsilon)-Structural mechanism to understand IKBKE as a pote…
FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex
ERK1/2-SmaV: Phospho ERK1/2 binding analysis with SmaV and structural characteriza…
Human a3 (IV) NC1: structural and binding analysis to integrin receptors Collabora…
CHK1/2 (Checkpoint kinase 1/2): Structural integrity of CHK1/2 in tumorigenesis
MDC1 ( Mediator of DNA damage checkpoint protein 1): Structural and binding anal…
EPH-B2:Cell signaling and biophysical interaction analysis with ephrin Receptor Co…

Lab Members

Lipi Das
Senior Research Fellow
Lipi Das
Senior Research Fellow
Siddhartha Barua
Senior Research Fellow
Siddhartha Barua
Senior Research Fellow
Shubhashish Chakraborty
Senior Research Fellow
Shubhashish Chakraborty
Senior Research Fellow
Vaishnvee Chikhale
Junior Research Fellow
Vaishnvee Chikhale
Junior Research Fellow
R N Sawant
Technician
R N Sawant
Technician
Suchita Dubey
Senior Research Fellow
Suchita Dubey
Senior Research Fellow
Ulka U Sawant
Scientific Assistant
Ulka U Sawant
Scientific Assistant
Neha Mishra
Senior Research Fellow
Neha Mishra
Senior Research Fellow

PUBLICATIONS

2021
Genetic ablation of pregnancy zone protein promotes breast cancer progression by activating TGF-â/SMAD signaling. Breast Cancer Research and Treatment. 185(2):317-330 PMID: 33057846
Kumar R, Kuligina E, Sokolenko A, Siddiqui Q, Gardi N, Gupta S, Varma AK, Hasan SK (2021)
2020
Exome sequencing study of Russian breast cancer patients suggests a predisposing role for USP39. Breast Cancer Research and Treatment. 179(3): 731-742. PMID: 31754952
Kuligina ES, Sokolenko AP, Bizin IV, Romanko AA, Zagorodnev KA, Anisimova MO, Krylova DD, Anisimova EI, Mantseva MA, Varma AK, Hasan SK, Ni VI, Koloskov AV, Suspitsin EN, Venina AR, Aleksakhina SN, Sokolova TN, Milanoviæ AM, Schürmann P, Prokofyeva DS, Bermisheva MA, Khusnutdinova EK, Bogdanova N, Dörk T, Imyanitov EN (2020)
Phosphorylation of deinococcal RecA affects its structure and function dynamics implicated for its roles in radioresistance of Deinococcus radiodurans. Journal of Biomolecular Structure and Dynamics. 38(1): 114-123. PMID: 30688163
Sharma DK, Siddiqui MQ, Gadewal N, Kumar Choudhary R, Varma AK, Misra HS, Rajpurohit YS (2020)
miRNA-mRNA profiling reveals prognostic impact of SMC1A expression in acute myeloid leukemia. Oncol Res. 2020 Feb 14. doi: 10.3727/096504020X15816752427321
Gadewal N, Kumar R, Aher S, Gardane A, Gaur T, Varma AK, Khattry N, Hasan SK

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Contact

Office Contact

Dr. Ashok K Varma

KS 101, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5112 avarma@actrec.gov.in Lab Website

Principal Investigator

Lab Website

Dr. Ashok K Varma

Research Interests

RESEARCH

Ongoing Research Projects

BRCA1(Breast Cancer Associated Domain-1):Three dimensional structural characteriza…

IKBKE(I-kappa-B kinase epsilon)-Structural mechanism to understand IKBKE as a pote…

FANCI-FANCD2- Structural basis of Fanconi anemia protein- FANCI-FANCD2 complex

ERK1/2-SmaV: Phospho ERK1/2 binding analysis with SmaV and structural characteriza…

Human a3 (IV) NC1: structural and binding analysis to integrin receptors Collabora…

CHK1/2 (Checkpoint kinase 1/2): Structural integrity of CHK1/2 in tumorigenesis

MDC1 ( Mediator of DNA damage checkpoint protein 1): Structural and binding anal…

EPH-B2:Cell signaling and biophysical interaction analysis with ephrin Receptor Co…

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. Ashok K Varma

For Research Scientist

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