Scientific Officer D
My research involves understanding mechanisms that regulate response to replication stress in cells. Specifically, we are identifying and characterizing the functions of proteins involved in stabilization of stalled replication forks, using mammalian cell cultures and Drosophila melanogaster as model systems. Many components of homologous- recombination (HR) mediated DNA repair are involved in replication-stress response where their functions are mechanistically different and remain poorly understood. This study focuses towards understanding the cellular responses to replication stress and their implications in tumorigenesis as well as resistance to radiation therapy. We are also interested in understanding how different regions in a tissue acquire variations in physiology, number and turnover rates of resident adult stem cells and why some tissues are susceptible to tumor formation than others. Specifically, we are studying the factors that regulate epithelial homeostasis using Drosophila midgut as a model system.
Functional characterization of a novel cancer associated gene named BRCA2 and CDKN1A Interacting Protein (BCCIP)… more
This study aims towards elucidating mechanisms that regulate stem cell identity and maintenance during hom… more
Mehrotra S*., Bansal P., Oli N., Pillai SJ and Galande S.
Mansuri MS and Mehrotra S*,
Zhang B., Mehrotra S., Ng WL., and Calvi BR.