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Research Projects

Genetic and functional characterization of high risk acute promyelocytic leukemia

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With the advent of targeted therapy using arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) very high cure rates (>90%) can be achieved in low/intermediate risk group APLs However, high risk group patients (white blood cell counts >10000/ul) still requires chemotherapy. The majority of post-remission deaths and relapses are linked to high risk group patients due to toxicity associated with chemotherapy or acquired ATO resistance. We plan to study the molecular & functional characteristics of high risk APL using patients’ samples, cell lines and orthotopic mouse models of APL.

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