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Research Projects

Evaluation of in vitro effects of novel small molecule inhibitors on primary patient-derived Multiple Myeloma cells

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Cyclin-dependent kinases (CDKs) regulate cell cycle and cell proliferation. CDK inhibition is predominantly successful in hematologic malignancies, which are more sensitive to inhibition of cell cycling and apoptosis induction. With the promising results of CDK7 inhibition using a novel small molecule inhibitor (AU-14227) in AML, we plan to investigate AU-14227 role in primary cells derived from multiple myeloma patients followed by functional validation using in vitro and in vivo assays.

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