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Research Projects

Evaluation of oral Withaferin-A for prophylaxis against acute Graft versus Host Disease in murine model of allogeneic hematopoietic stem cell transplantation.


We are currently focusing on developing new strategies to make allogeneic Bone Marrow Transplantation (BMT) safer and more effective. One of our focus areas in this setting is the development of strategies against graft versus host disease (GvHD), the most common complication of allogeneic transplantation. To address this problem, we are developing Withaferin-A (an immunomodulatory phytochemical) as a potential candidate against GvHD and the initial results are encouraging. We are currently investigating the effect of Withaferin-A on the Graft versus Tumor (GvT) response which is a prerequisite before any drug can be considered as a candidate for anti-GvHD prophylaxis.

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