Scientific Officer
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- Dr . Sonam Mehrotra
Dr . Sonam Mehrotra
Scientific Officer D
Honors and Recognitions
- WELLCOME-DBT INDIA ALLIANCE INTERMEDIATE FELLOW
- DBT-BIOCARE FELLOW (2014-2016)
Research Interests
- Understanding mechanisms of replication stress response and their implications in tumor initiation, progression, therapy and development of resistance.
- Functional characterization of DNA repair proteins during replication stress response
- Epithelial cell homeostasis using Drosophila midgut as model system
RESEARCH
My research involves understanding mechanisms that regulate response to replication stress in cells. Specifically, we are identifying and characterizing the functions of proteins involved in stabilization of stalled replication forks, using mammalian cell cultures and Drosophila melanogaster as model systems. Many components of homologous- recombination (HR) mediated DNA repair are involved in replication-stress response where their functions are mechanistically different and remain poorly understood. This study focuses towards understanding the cellular responses to replication stress and their implications in tumorigenesis as well as resistance to radiation therapy. We are also interested in understanding how different regions in a tissue acquire variations in physiology, number and turnover rates of resident adult stem cells and why some tissues are susceptible to tumor formation than others. Specifically, we are studying the factors that regulate epithelial homeostasis using Drosophila midgut as a model system.
