SRI

(Sorcin)

 

  • Alias                                 (According to NCBI)

 
  • Sorcin
  • SCN
  • FLJ26259
  • SRI

  • Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
  • Location: 7q21.1
  • Size: 21877 bp
  • exons:
  • DNA sequence (Human):  NC_000007.13

  • CGH (7q21.1):  Losses (%) -4.5   Gain (%) 11.2    

  • Mutations and SNPs (According to HGMD and SNP)

 
  • HGMD :
  • SNPs: SRI

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 198 amino acids; 21676 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side

  • Protein domains

     

  • Protein sequence (Human): P30626

  • Homologous genes:

  • 2D PAGE:

  • 3D Structure:1JUO

  • PTM:

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: P30626
  • Clinical                            (According to OMIM, PubMed)