Activation and death of γδ T lymphocytes in patients with oral cancer
Chiplunkar, Atre (SRF), Pathak, D’Cruz
 
γδ T cells play an important role as anti-tumor effector cells. However, their expansion is self-limiting. We investigated the activation induced cell death in γδ T cells after stimulation with heat shock proteins (hsp60, hsp70) that act as ligands for γδ T cells. Characterization of the molecular events in the apoptotic pathway revealed that nitric oxide (NO) is released by γδ T cells after hsp stimulation. Purified γδ T cells when incubated with rhsp60 and rhsp70 as well as artificial NO donors - SNAP and arginine, exhibited changes in mitochondrial membrane potential. Addition of caspase-9 inhibiting peptide Z-LEHD-FMK inhibited DNA fragmentation in γδ T cells and mitochondrial membrane potential changes, indicating involvement of caspases-9 in hsp60/70 induced apoptosis of γδ T cells. Our studies demonstrated a unique strategy adopted by tumor cells to evade immune recognition.
 

Potential of γδ T lymphocytes stimulated with non-peptidic antigens for immunotherapy of cancer 
Chiplunkar, Dhar, Pathak, Badwe 

Toll-like receptors and antitumor immunity: Role of γδ T lymphocytes 
Chiplunkar, Paleja, Tongaonkar, D’Cruz, Kane, Deodhar

Role of alkylamines in priming γδ T lymphocytes for antitumor effector functions
Chiplunkar, K Nirmala, Tongaonkar, D’Cruz, Kane, Deodhar

Analysis of clonal TCR and gene rearrangements in T-ALL: Significance in diagnosis and prognosis 
Chiplunkar, Kode, Dudhal, Banavali 

Immune scenario in cervical cancer patients: Role of HPV and NKT cells 
Chiplunkar, B Ravi Kiran, Tongaonkar, Dinshaw 

Down regulation of CD3-zeta chain expression in T cells of oral cancer patients: a potential biomarker for prognosis 
Chiplunkar, Rao, Pradhan, Pathak, D’Cruz, Kane, Shastri, Srivastava, Chaturvedi, Agarwal 

Role of cycloxygenases and its inhibitors in lymphocyte activation and in restoring anti tumor immunity 
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