Dr. Kakoli Lab
Integrated Biophysics and Structural Biology lab
The focus of the laboratory is to understand the underlying mechanism of alternative non-classical mechanisms of programmed cell death (apoptosis). Apoptosis is a fundamental cellular process essential to maintain a healthy life. Disruption of the fine balance between cell survival and death leads to several life-threatening diseases such as neurodegenerative disorders and cancer. Cancer is characterized by a breakdown in the cellular apoptotic machinery, which might be due to alteration of structural and functional properties of critical proteins in the apoptotic pathway. Interaction between pro- and anti-apoptotic proteins is closely related to the genesis and progression of cancer. Therefore, identifying the binding partners of pro-apoptotic proteins and understanding the determinants of such interactions will not only help delineate their biological roles but will also help design their peptide and non-peptide mimetics that would disrupt the interactions, promote apoptosis and hence regulate tumorigenesis.
Research Tools: Biophysics, in silico studies, protein biochemistry, enzymology, molecular, cell and structural biology
Dr. Kakoli Bose, Ph. D.
M.Sc. : Science College, Kolkata
Ph.D. : North Carolina State
Post Doc: Tufts University Boston,