Dutt Lab in News

Novel genetic marker identified for lung adenocarcinoma

As lifestyles change, and an increasing number of people get exposed to rising pollutants, the susceptibility towards non-communicable diseases like lung cancer has also increased. Therapeutic interventions for lung cancer include surgery, chemotherapy, radiation therapy and targeting known genetic mutations. The treatment plan depends on the type of cancer a patient has.
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Non-typhoidal Salmonella in gallbladder cancer

Gallbladder Cancer (GBC) is relatively rare compared to more common cancers of the lungs, breast, prostate and colon. However, it has emerged as a silent killer among North Indian women—the disease is usually detected only in the advanced stages when the mean survival rate for patients is around 6 months. Only 5% of the patients make ...
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First comprehensive description of druggable mutation spectrum in lung cancer patients in India

The observed mutational diversity underlying cancer genomes is in line with the varied clinical response found in cancer patients based on their ethnicity, divergent genetic structure and exposure to environmental factors.
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Non-typhoidal Salmonella DNA traces in gallbladder cancer

Gallbladder cancer is a relatively rare cancer in developed nations with an incidence as low as 1–2.5 per 100,000. However in South America and India gallbladder cancer remains a major problem with the disease presenting at an advanced stage and occurring at an incidence of 15.5 and 21.5 per 100,000, respectively.
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First Indian germline database to catalog the variations in the genome of Indian population

Cancer is a genetic disease caused by a sequential accumulation of mutations in the genome. Unlike normal cell genomes, a typical cancer cell genome harbors two kinds of variations: in addition to post birth acquired somatic mutations that are associated with the disease.....
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Novel therapeutic target for early stage tongue cancer

Notch signaling pathway is a highly conserved cell signaling pathway present in most multicellular organisms. Mammals have four notch receptors, Notch1, Notch2, Notch3 and Notch4 which are present on the surface of the cell.
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Dutt lab on Science Radio by IISER Pune