Interactome Map

Genes belongs to major biological process and molecular functions categories are listed in table below. HIMAP tool was used to predict human protein-protein interaction map for each categories. [ Daniel R Rhodes et. al., Probabilistic model of the human protein-protein interaction network, Nature Biotechnology 23, 951 - 959, 2005 ]

Instructions: 1. Click here to download the SVG viewer from Adobe to view the Interactome Map. Click on the SGV viewer file for your operating system from the table. Click on "Run" and again Click on "Run".

2. Click on Interactome Map to open and click 'accept' to agree the license agreement.

3. For browsing the Interactome Map, right-click on Map to 'Zoom In' and 'Zoom Out' . 'Original view' to reset.

Biological Process	Genes	No. of genes	Percentage	Interactome Map (Download SVG Viewer to view the link enable Map )
Signal Transduction	HIF1A IL8RB RB1 ITGA6 SCAP2 TNFRSF6 IFITM1 ABL1 Stat3 FYB CTNNBIP1 TNFSF6 ANXA1 SFN EGFR GSK3B TNFRSF10B TGFB1 NMU CRYAB VEGFC VEGFA SKIL TNFRSF10A Hras BAG1 RRAS WNT14 CEACAM6 ITGB4 PCNA EPHB4 APC COL1A2 LAMR1 LGALS1 LEPR FGF4 IGF2R AKT3 KIFAP3 ErbB2 C3 VEGFB TIMP3 PLAU UBD STAT5B PECAM1 FGF3 PDGFA PRDX4 MST1R PLCG1 CXCR4 FGG IL4R	57	28.36
Cell Proliferation	KRT16 IL8RB IFITM1 p53 TGFB2 TGFA CTNNBIP1 SFN EGFR CDKN1B TGFB1 Bcl2 MDM2 VEGFC KRT6A MYC VEGFA p21 CDK6 NME1 PCNA EPHB4 MKI67 CDK4 PHB TAl1 FGF4 ErbB2 TIMP1 VEGFB PDGFB NPM1 CDKN2A IGFBP7 FGF3 PDGFA MST1R E2F1 FGG TSPAN2 MTS2 ETS1	42	20.9
Response to Stress	HIF1A IL8RB XRCC1 S100A9 TP53 ABL1 Stat3 ANXA1 EGFR APOL2 HSPCB XPC Bcl2 SOD2 HSPD1 VEGFA BF GSTT1 IFI44 PCNA MGMT CHES1 GPX3 HSPB1 C3 PLAU PDGFB NPM1 KRT1 UBD PTGS2 ANXA5 FGG NOS2A HSP70	35	17.16
Apoptosis	TNFRSF6 p53 ABL1 TNFSF6 XIAP TNFRSF10B TGFB1 GAL7 Bcl2 VEGFA p21 Bax TNFRSF10A BAG1 BCL2L1 BIRC5 LGALS1 DNASE1L3 ZAC E2F1	20	10.53

NOTE: Orange colour node in Map is default colour, green colour node indicate genes involve in 'transcription factor', blue colour node indicate genes are 'receptor' and red colour node indicate genes are 'kinases'.

Molecular Function	Genes	No. of genes	Percentage	Interactome Map (Download SVG Viewer to view the link enable Map )
Ion binding	MMP14 HIF1A MMP7 ITGA6 S100A9 MMP10 TP53 PEG3 FHIT Stat3 BAT1 PTGS1 ANXA1 BIRC4 ANXA2 S100A7 MDM2 SOD2 SCEL HBB CDKN1A DZIP1 ATP5B CA2 MMP3 NME1 FAT ATP2A2 CYP2D6 DSG1 BIRC5 CDH17 DNASE1L3 CYP1A1 WT1 PLAGL1 ZNF273 MMP11 STAT5B TGM3 MYL1 S100A4 PTGS2 TCF20 PLCG1 ANXA5 FGG NOS2A ALB ENO1	48	24.12
Nucleic acid binding	HIF1A DOC1 RB1 XRCC1 TP53 PEG3 ABL1 Stat3 BAT1 EGFR XPC MYC DZIP1 TERT NME1 EIF4E PCNA MGMT CHES1 TAl1 DNASE1L3 WT1 PLAGL1 ZNF273 NPM1 STAT5B EEF1A1 NFE2L2 ZRF1 TCF20 E2F1 ETS1	32	16.08
Hydrolase activity	MMP14 MMP7 EPHX1 MMP10 TP53 FHIT BAT1 PPP1R3C CTSD HGF BF ZAP70 Hras ATP5B MMP3 RRAS NME1 ATP2A2 ABCB4 SHH CTSB PTPN13 HEXA DNASE1L3 PLAU MMP11 EEF1A1 CES1 PLCG1 ENO1	29	14.57
Transferase activity	SCAP2 TGFA ABL1 EGFR GSK3B GSTM1 PAPSS2 CDKN1A CDK6 GSTT1 TERT NME1 CHKA PCNA EPHB4 MGMT CDK4 IGF2R AKT3 ErbB2 GSTM3 PLAU CDKN2A TGM3 MST1R MTS2	26	13.07
Nucleotide binding	TP53 ABL1 BAT1 EGFR ACTB GSK3B ACTG1 PAPSS2 HSPCB HSPD1 CDK6 Hras ATP5B RRAS NME1 ATP2A2 ABCB4 EPHB4 MKI67 CDK4 AKT3 ErbB2 EEF1A1 MST1R NOS2A HSP70	26	13.07
R eceptor binding	NRG1 RB1 TGFB2 TGFA IK FYB TNFSF6 ANXA1 APOL2 HGF TGFB1 NMU VEGFC VEGFA FGF4 ErbB2 C3 VEGFB PDGFB FGF3 PDGFA DBI	22	11.06
R eceptor activity	IL8RB ITGA6 TNFRSF6 ICAM1 EGFR TNFRSF10B NPR3 CD1A TNFRSF10A ITGB4 EPHB4 LAMR1 LEPR IGF2R ErbB2 CD44R KRT1 UBD MST1R CXCR4 IL4R	21	10.55
Enzyme inhibitor activity	ANXA1 BIRC4 SFN CDKN1B ANXA2 CDKN1A CSTB TIMP2 BIRC5 C3 TIMP1 TIMP3 CDKN2A NFE2L2 ANXA5 MTS2	16	8.04
O xidoreductase activity	HIF1A PTGS1 ALDH8 SOD2 ALDH10 ALDH5A1 HPGD CYP2D6 GPX3 CYP1A1 MAOB PRDX4 PTGS2 NOS2A YWHAB LDHA	14	7.04
Transcription factor activity	HIF1A RB1 TP53 PEG3 Stat3 MYC CHES1 WT1 STAT5B NFE2L2 E2F1 ETS1	12	6.03