XPC

                                                     (Xeroderma pigmentosum, complementation group C)

  • Alias                                 (According to NCBI)

 
  • XP3 
  • XPCC
  • xeroderma pigmentosum, complementation group C
  • DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C complementing protein) (p125)

  • Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. XP-C is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.
  • Location: 3p25
  • Orientation: Minus strand
  • Size: 33,436 bases
  • 19 Exons
  • DNA Sequence: NT_022517

  • CGH (3p25): Losses (%) -5.0   Gain (%)  1.3   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 939 amino acids; 105849 Da
  • Sub cellular location: Nuclear
  • Protein domains:

                                                          
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)