XIAP/BIRC4

                                                                                           (X-linked inhibitor of apoptosis)                     

  • Alias                                 (According to NCBI)

 
  • API3
  • ILP1
  • MIHA
  • XIAP 
  • Xiap 
  • hILP 
  • X-linked inhibitor of apoptosis
  • apoptosis inhibitor 3
  • baculoviral IAP repeat-containing 4
  • Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor
    of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP)

  • The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7
  • Location: Xq25
  • Orientation: Plus strand
  • Size: 53,774 bases
  • 7 Exons
  • DNA Sequence: NT_077819

  • CGH (Xq25): Losses (%) -1.3   Gain (%)  10.0   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 497 amino acids; 56684 Da
  • Sub cellular location: Cytoplasmic
  • Protein domains:

                                                         
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)