• Alias                                 (According to NCBI)

• Description   

  (According to SwissProt)

• This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location:11p13
• Orientation: minus  strand
• Size: 47753 bp
•  9 exons
• DNA sequence (Human):  NC_000011 

• CGH (11p13): Losses (%) -7.5   Gain (%)  2.5   Amplifications  0.0

• Mutations and SNPs  (According to HGMD and SNP)

• HGMD :  WT1
• SNPs: WT1

• m-RNA                           (According to NCBI and CGAP)

• mRNA sequence (Human): NM_000378 , NM_024424, NM_024425, NM_024426

• Size: 2969 bp, 3020 bp , 2978 bp , 3029 bp

• cDNA libraries:WT1

• Protein                                  (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 449 amino acids; 49188 Da
• Catalytic activity:

• Subcellular location: Nuclear.

• Protein domains

 

• Protein sequence (Human): P19544

• Homologous genes:WT1

• 2D PAGE: P19544

• 3D Structure: 1LU6 (3D)   

• PTM: WT1
   

• Pathways and interactions (According to BioCarta, DIP)

• Pathway

Chaperones modulate interferon Signaling Pathway

Overview of telomerase protein component gene hTert Transcriptional Regulation

• Protein interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Clinical                            (According to OMIM, PubMed)

• OMIM: 607102

• PubMed:  Early detection      Diagnosis      Prognosis      Therapy