VEGF-C

                                                                                      (vascular endothelial growth factor C)

  • Alias                                 (According to NCBI)

 
  • Flt4-L 
  • VRF
  • FLT4 ligand DHM 
  • vascular endothelial growth factor C
  • vascular endothelial growth factor-related protein
  • Vascular endothelial growth factor C precursor (VEGF-C) (Vascular endothelial growth factor related protein) (VRP) (Flt4 ligand) (Flt4- L).

  • The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
  • Location: 4q34.1-q34.3
  • Orientation: Minus strand
  •  Size:109,204 bases
  •  7 Exons
  •  DNA Sequence: NT_022792

  • CGH (4q34.1 - 34.3): Losses (%) -13.8   Gain (%)  1.8   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  •  Size:419 amino acids; 46883 Da
  • Sub cellular location: Secreted
  • Protein domains: 

                            

  • Pathways and interactions (According to BioCarta, DIP)
      

  • Clinical                            (According to OMIM, PubMed)