UCp2

(Uncoupling Protein 2)

 

  • Alias                                 (According to NCBI)

 
  • SLC25A8 
  • UCPH 
  • Uncoupling protein-2 
  • uncoupling protein 2 (mitochondrial, proton carrier) 
  • Mitochondrial uncoupling protein 2 (UCP 2) (UCPH).
  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
  • Location:11q13
  • Orientation: minus strand
  • Size: 8174 bp
  • 8 exons
  • DNA sequence (Human): NC_000011.

  • CGH (11q13): Losses (%) -3.8   Gain (%)  13.8   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 

        

                     
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)