TUBA1

Tubulin alpha 1 (testis specific)

 

  • Alias                                 (According to NCBI)

 
  • FLJ30169
  • H2-ALPHA
  • tubulin, alpha 1 (testis specific)
  • Tubulin alpha-1 chain (Alpha-tubulin 1) (Testis-specific alpha- tubulin) (Tubulin H2-alpha).

  • Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
  • Location: 2q35  
  • Orientation: minus strand
  • Size: 3638 bp
  • 4 exons
  • DNA sequence (Human):  NC_000002 


  • CGH (2q35): Losses (%) -8.8   Gain (%)  3.8   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 448 amino acids; 49924 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)