TGM3

Transglutaminase 3

 

  • Alias                                 (According to NCBI)

 
  • TGE
  • TGase E
  • transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
  • transglutaminase E
  • Protein-glutamine glutamyltransferase E precursor (EC 2.3.2.13) (TGase E) (TGE) (TG(E))
    (Transglutaminase 3).

  • Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.
  • Location: LocusLink cytogenetic band: 20q11.2   
  • Orientation: plus strand
  • Size: 45,050 bp
  • 13 exons
  • DNA sequence (Human):  NC_000020  


  • CGH (20q11.2): Losses (%) -2.5   Gain (%)  11.3   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:693 amino acids; 76631 Da
  • Catalytic activity: Protein glutamine + alkylamine = protein N(5)- alkylglutamine + NH(3).

  • Subcellular location:

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)