TCF20

(Transcription factor 20 (AR1))

 

  • Alias                                 (According to NCBI)

 
  • AR1 
  • KIAA0292 
  • SPBP
  • SPRE-binding protein
  • nuclear factor SPBP
  • stromelysin 1 PDGF-responsive element-binding protein
  • stromelysin-1 platelet-derived growth factor-responsive element binding protein
  • transcription factor 20
  • transcription factor 20 (AR1)
  • Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding
    protein) (Nuclear factor SPBP) (AR1).
  • The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.
  • Location: 22q13.3
  • Orientation:  minus strand
  • Size: 55427 bp
  • 5  exons
  • DNA sequence (Human): NC_000022 

  • CGH (22q13.3): Losses (%) -6.3   Gain (%)  10.0   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 1960 amino acids; 211798 Da
  • Catalytic activity:

  • Subcellular location: Nuclear.

  • Protein domains

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  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)