STAG2

Stromal Antigen 2

 

  • Alias                                 (According to NCBI)

 
  • SA-2 
  • SA2
  • stromal antigen 2
  • Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

  • Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
  • Location: xq25
  • Orientation: plus strand
  • Size: 140758 bp
  • 34 exons
  • DNA sequence (Human): NC_000023

  • CGH (Xq25): Losses (%) -1.3   Gain (%)  10.0   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 1162 amino acids; 134071 Da
  • Catalytic activity:

  • Subcellular location:  Nuclear protein. Associates with chromatin. Before prophase it is scattered
    along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin
    probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain.
    At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex
    from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from
    chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)