SOD2

                                                                    (Superoxide dismutase 2, mitochondrial)

  • Alias                                 (According to NCBI)

 
  • IPO-B
  • MNSOD
  • manganese superoxide dismutase
  • superoxide dismutase 2, mitochondrial
  • Superoxide dismutase [Mn], mitochondrial precursor (EC 1.15.1.1).

  • Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
  • Location: 6q25.3
  • Orientation: Minus strand
  • Size: 11,031 bases
  • 5 Exons
  • DNA Sequence: NT_007422

  • CGH (6q25.3): Losses (%) -12.5   Gain (%)  2.5   Amplifications  0.0
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:222 amino acids; 24722 Da
  • Sub cellular activity: Mitochondrial matrix
  • Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)
  • Protein domains:

                                                  
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)