-
Alias (According to NCBI)
- RB
- Retinoblastoma-1
- retinoblastoma 1 (including osteosarcoma)
- Retinoblastoma-associated protein (PP110) (P105-RB) (RB)
-
Description
(According to SwissProt)
-
Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Probably acts as a regulator of other genes. Forms a complex with adenovirus E1A and with SV40 large T antigen. Acts as a tumor suppressor. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. Potent inhibitor of E2F-mediated trans-activation. Recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. Inhibits the intrinsic kinase activity of TAF1.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location:13q 14.2
- Orientation: Plus strand
- Size: 178,211 bases
- 27 Exons
- DNA Sequence:NT_024524
- CGH (13q14.2): Losses (%) - 8.8 Gain (%) 1.3 Amplifications 0.0
- Size: 928 amino acids; 106159 Da
- Protein domains:
- Sub cellular location: Nuclear
- Protein sequence:P06400
- Homologous genes: Rb1
- 3D Structure:1GH6
- PTM: RB
- Pathways: Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
- Antigen Dependent B Cell Activation
- Attenuation of GPCR Signaling
- B Lymphocyte Cell Surface Molecules
- Bystander B Cell Activation
- Cell Cycle: G1/S Check Point
- Chaperones modulate interferon Signaling Pathway
- Cyclin E Destruction Pathway
- Cyclins and Cell Cycle Regulation
- Cytokines and Inflammatory Response
- E2F1 Destruction Pathway
- Eph Kinases and ephrins support platelet aggregation
- FAS signaling pathway ( CD95 )
- HIV-I Nef: negative effector of Fas and TNF
- Human Cytomegalovirus and Map Kinase Pathways
- IL 3 signaling pathway
- IL 5 Signaling Pathway
- IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
- Influence of Ras and Rho proteins on G1 to S Transition
- Lck and Fyn tyrosine kinases in initiation of TCR Activation
- Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
- NO2-dependent IL 12 Pathway in NK cells
- Overview of telomerase RNA component gene hTerc Transcriptional Regulation
- p53 Signaling Pathway
- RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
- Regulation of BAD phosphorylation
- Regulation of p27 Phosphorylation during Cell Cycle Progression
- Regulation of transcriptional activity by PML
- Selective expression of chemokine receptors during T-cell polarization
- Telomeres, Telomerase, Cellular Aging, and Immortality
- Th1/Th2 Differentiation
- The Co-Stimulatory Signal During T-cell Activation
- The Role of Eosinophils in the Chemokine Network of Allergy
- TNFR1 Signaling Pathway
- Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
- Protein Interactions: 582N
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB000095
- OMIM: 180200
- PubMed: Early detection Diagnosis Prognosis Therapy