PLAU

Plasminogen Activator, Urokinase

 

  • Alias                                 (According to NCBI)

 
  • UPA 
  • URK
  • U-plasminogen activator
  • plasminogen activator, urinary
  • plasminogen activator, urokinase
  • urokinase-type plasminogen activator precursor 
  • Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator).

  • This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
  • Location: 10q24
  • Orientation: plus strand
  • Size:  6318 bp
  • 10 exons
  • DNA sequence (Human): NC_000010

  • CGH (10q24):  Losses (%) - 8.8   Gain (%)  0.0   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 431 amino acids; 48525 Da
  • Catalytic activity: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

  • Subcellular location:

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

          Fibrinolysis Pathway

  • Protein interactions: 137N
 
  • Clinical                            (According to OMIM, PubMed)