PKP3

(Plakophilin)

 

  • Alias                                 (According to NCBI)

 
  • Weakly similar to band-6-protein [H.sapiens]
  • plakophilin 3
  • Plakophilin 3.
  • This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.
  • Location: 11p15
  • Orientation: plus strand
  • Size: 10684 bp 
  •  13 exons
  • DNA sequence (Human): NC_000011  

  • CGH (11p15):  Losses (%) - 7.5   Gain (%)  2.5   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:  797 amino acids; 87081 Da
  • Catalytic activity:
  • Subcellular location: Nuclear and associated with desmosomes.
    Protein domains

        

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)