PHB

(Prohibitin)

Alias (According to NCBI)	prohibitin breast cancer, sporadic Prohibitin.
Description (According to SwissProt)	Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
Chromosomal location (According to NCBI, CGH: progenetix)	Location: 17q21 Orientation: minus strand Size: 10823 bp 7 exons DNA sequence (Human): NC_000017 CGH (17q21): Losses (%) - 2.5 Gain (%) 6.3 Amplifications 0.0
Mutations and SNPs (According to HGMD and SNP)	HGMD : PHB SNPs: PHB
m-RNA (According to NCBI and CGAP)	mRNA sequence (Human): NM_002634 Size: 1826 bp cDNA libraries: PHB
Protein (According to SwissProt, Swiss2D, PDB, dbPTM)	Size: 272 amino acids; 29804 Da Catalytic activity: Subcellular location: Cytoplasmic. Protein domains Protein sequence (Human): P35232 Homologous genes: PHB 2D PAGE:P35232 3D Structure: 1LU7 PTM: PHB
Pathways and interactions (According to BioCarta, DIP)	Pathway: Protein interactions: 24248N
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA): CAB001517
Clinical (According to OMIM, PubMed)	OMIM: 176705 PubMed: Early detection Diagnosis Prognosis Therapy