p27/ CDKN1B

                                                                 (cyclin-dependent kinase inhibitor 1B)

  • Alias                                 (According to NCBI)

 

  
  • CDKN4
  • KIP1
  • P27KIP1
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1) 
  • Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1).
  • The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Therefore  involved in  G1 arrest. It is under expressed in the development and
    progression of oral squamous cell carcinoma
  • Location:12p13.2
  • Orientation: Plus strand
  • Size:4,993 bases
  • 3 Exons
  • DNA Sequence:NT_009714

            

  • CGH (12p13.2):  Losses (%) - 7.5   Gain (%)  3.8   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)

        

 
  • m-RNA                       (According to NCBI and CGAP)

 

 
  • Size:198 amino acids; 22073 Da
  • Sub cellular location: Nucleus
  • Protein domains:

                             

 
  • Pathways and interactions (According to BioCarta, DIP)
     

Protein interactions:
  • Clinical                            (According to OMIM, PubMed)