NFE2L2

(Nuclear factor (erythroid derived 2))

 

  • Alias                                 (According to NCBI)

 
  • NRF2
  • nuclear factor (erythroid-derived 2)-like 2
  • Nuclear factor erythroid 2 related factor 2 (NF-E2 related factor 2) (NFE2-related factor 2)
    (Nuclear factor, erythroid derived 2, like 2) (HEBP1).
  • NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995).
  • Location: 2q31
  • Orientation: minus  strand
  • Size: 34379 bp
  •  5 exons
  • DNA sequence (Human): NC_000002 

  • CGH (2q31):  Losses (%) -8.8   Gain (%)  3.8   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD (Human Gene Mutation Database):
  • SNPs: NFE2L2
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 605 amino acids; 67826 Da
  • Catalytic activity:

  • Subcellular location: Nuclear (By similarity).
    Protein domains

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  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

          Oxidative Stress Induced Gene Expression Via Nrf2

 

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)