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Alias (According to NCBI)
- CAP43
- CMT4D
- DRG1
- GC4
- HMSNL
- NDR1
- NMSL
- PROXY1
- RIT42
- RTP
- TARG1
- TDD5
- Human mRNA for RTP, complete cds
- N-myc downstream regulated
- N-myc downstream regulated gene 1
- N-myc downstream regulated gene 1 protein
- differentiation-related gene 1 protein
- nickel-specific induction protein Cap43
- protein regulated by oxygen-1
- reducing agents and tunicamycin-responsive protein
- NDRG1 protein (N-myc
downstream regulated gene 1 protein) (Differentiation-related gene 1
protein)
(DRG1) (Reducing agents and tunicamycin-responsive protein) (RTP) (Nickel-specific induction
protein Cap43) (Rit42).
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Description
(According to SwissProt)
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This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 8q24.3
- Orientation: minus strand
- Size: 60,415 bp
- 16 exons
- DNA sequence (Human): NC_000008
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CGH (8q24.3): Losses (%) -0.0 Gain (%) 26.3 Amplifications 0.0
- Size: 394 amino acids; 42835 Da
- Catalytic activity:
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Subcellular location: Whereas in prostate epithelium and placental chorion it is located in both the cytoplasm and the nucleus, nuclear staining is not observed in colon epithelium cells. Instead its localization changes from the cytoplasm to the plasma membrane during differentiation of colon carcinoma cell lines in vitro.
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Protein domains
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Pathway:
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Protein interactions:
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA):
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OMIM: 605262
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PubMed: Early detection Diagnosis Prognosis Therapy