NDPK /NME1

(Nucleoside Diphosphate Kinase) 

  • Alias                                 (According to NCBI)

 
  • NME1
  • AWD 2
  • GAAD 2
  • NDPKA 2
  • NM23 2
  • NM23-H1 2
  • non-metastatic cells 1, protein (NM23A) expressed in 1, 2, 5
  • Nucleoside diphosphate kinase A (EC 2.7.4.6) (NDK A) (NDP kinase A) (Tumor metastatic process-associated protein) (Metastasis inhibition factor nm23) (nm23-H1) (Granzyme A-activated DNase) (GAAD). 3
  • NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. NME1 encodes the 'A' isoform of nucleoside diphosphate kinase (NDK). NDK exists as a hexamer composed of the 'A' (NME1) and 'B' (encoded by NME2) isoforms. Mutations in NME1 have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene.
  • Location: 17q21.3
  • Orientation: plus strand
  • Size: 8,530 bp
  • 5  exons
  • DNA sequence (Human): NC_000017.

 

  • CGH (17q21.3):  Losses (%) -2.5   Gain (%)  6.3   Amplifications  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

 
  • Size: 152 amino acids; 17149 Da
  • Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

·         Subcellular location: Nuclear and cytoplasmic.

·         Protein domains

        

 

  • ·         Protein sequence (Human): P15531

  • ·         Homologous genes: NDPK

  • ·         2D PAGE: P15531

  • ·         3D Structure: 1JXV    

  •           PTM: NDPK
  • Pathways and interactions (According to BioCarta, DIP)

 

  •  Pathway:

       Endocytotic role of NDK, Phosphins and Dynamin

 

Granzyme A mediated Apoptosis Pathway

 

  • Protein interactions:

 

 

 
  • Clinical                            (According to OMIM, PubMed)