MST1R

                                                                                     (Macrophage stimulating 1 receptor)

  • Alias                                 (According to NCBI)

 

  • CDw136
  • RON
  • macrophage stimulating 1 receptor (c-met-related tyrosine kinase) 
  • Macrophage-stimulating protein receptor precursor (EC 2.7.1.112) (MSP receptor) (p185-Ron) (CDW136) (CD136 antigen)
  • It is the receptor for macrophage stimulating protein (MSP) and has a tyrosine-protein kinase activity. It is predominantly expressed in keratinocytes and lung.
  • Location: 3p21.3
  • Orientation: Minus strand
  • Size: 16,632 bases
  • 20 Exons
  • DNA Sequence: NT_022517

  • CGH (3p21.3):  Losses (%) -5.0  Gain (%)  0.0  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  • Size:1400 amino acids; 152227 Da
  • Sub cellular location: Type I membrane protein
  • Catalytic activity: ATP + a protein tyrosine = ADP + protein tyrosine phosphate
  • Protein domains:

                                               

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)