MRPL13

                                                                              (Mitochondrial ribosomal protein L13)

  • Alias                                 (According to NCBI)

 
  • HGNC:15637
  • L13
  • L13mt
  • RPL13
  • mitochondrial ribosomal protein L13 
  • 60S ribosomal protein L13, mitochondrial (L13mt)

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
  • Location: 8q22.1-q22.3
  • Orientation: Minus strand
  • Size: 49,564 bases
  • 7 Exons
  • DNA Sequence: NT_008046

  • CGH (8q22.1-22.3):  Losses (%) -0.0  Gain (%)  23.8  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 178 amino acids; 20692 Da
  • Protein domains:

                                                              
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)