MPP11

                                                                                            (M-phase phosphoprotein 11)

  • Alias                                 (According to NCBI)

 
  • DNAJC2
  • MPHOSPH11
  • MPP11
  • M-phase phosphoprotein 11 
  • Weakly similar to HYPOTHETICAL 31.6 KD PROTEIN F54F2.9 IN CHROMOSOME III [Caenorhabditis elegans]
  • zuotin related factor 1(ZRF1)
  • Zuotin related factor-1 (M-phase phosphoprotein 11)
  • This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
  • Location:7q22-q32
  • Orientation: Minus strand
  • Size: 33,585 bases
  • 15 Exons
  • DNA Sequence: NT_007933

  • CGH (7q22-32):  Losses (%) -3.8  Gain (%)  10.0  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:568 amino acids; 65913 Da
  • Sub cellular location: Nuclear
  • Protein domains:

                                              
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)