MMP-14

                                                                                            (matrix metalloproteinase 14)

  • Alias                                 (According to NCBI)

 
  • MMP-X1
  • MT1-MMP
  • MTMMP1
  • matrix metalloproteinase 14 (membrane-inserted)
  • membrane-type matrix metalloproteinase 1
  • membrane-type-1 matrix metalloproteinase
  • Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

  •  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
  • Location:14q11-q12
  • Orientation: Plus strand
  • Size:11,009 bases
  • 11 Exons
  • DNA Sequence: NT_026437

  • CGH (14q11-12):  Losses (%) -1.3  Gain (%)  8.8  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  
  •  Size:582 amino acids; 65883 Da
  • Subcellular location: Type I membrane protein (Potential)
  • Protein domains:

                                                     
  • Pathways and interactions (According to BioCarta, DIP)
 

  • Clinical                            (According to OMIM, PubMed)