MGMT

                                                                          (O-6-methylguanine-DNA methyltransferase)

  • Alias                                 (According to NCBI)

 
  • Methylguanine-DNA methyltransferase
  • O-6-methylguanine-DNA methyltransferase
  • Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA
    methyltransferase) (MGMT) (O-6-methylguanine-DNA- alkyltransferase)

  • It involved in the cellular defense against the biological effects of o6-methylguanine(o6-meg) in dna. repairs alkylated guanine in dna by stoichiometrically transferring the alkyl group at the o-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
  • Location: 10q26
  • Orientation: Plus strand
  • Size: 230,864 bases
  • 4 Exons
  • DNA Sequence: NT_008818

  • CGH (10q26):  Losses (%) -7.5  Gain (%)  1.3  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 207 amino acids; 21646 Da
  • Catalytic activity: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without
    6-O-methylguanine) + protein S-methyl-L- cysteine
  • Protein domains:

                         
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathway:
  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)