LEPR

Leptin Receptor

 

  • Alias                                 (According to NCBI)

 
  • OBR
  • OB receptor
  • leptin receptor 
  • Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219).
  • Leptin receptor gene-related protein (OB-R gene related protein) (OB- RGRP).

  • Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.
  • Location: 1p31
  • Orientation: plus strand
  • Size: 212191 bp
  • 20 exons
  • DNA sequence (Human): NC_000001

  • CGH (1p31):  Losses (%) -2.5  Gain (%)  2.5  Amplifications (%) 0.0
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:1165 amino acids; 132449 Da    
  • Catalytic activity:

  • Subcellular location: Type I membrane protein. Isoform E is probably secreted.

  • Protein domains

 
  • Pathways and interactions (According to BioCarta, DIP)

 
 
  • Clinical                            (According to OMIM, PubMed)