KRT19

(Keratin 19)

 

  • Alias                                 (According to NCBI)

 
  • CK19 
  • K1CS 
  • MGC15366 
  • 40-kDa keratin intermediate filament precursor gene 
  • KRT19 protein
  • cytokeratin 19 
  • keratin, type I cytoskeletal 19 
  • keratin, type I, 40-kd 
  • Keratin, type I cytoskeletal 19 (Cytokeratin 19) (K19) (CK 19).
  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.
  • Location:17q21.2
  • Orientation: minus strand
  • Size: 4765 bp
  • 6 exons
  • DNA sequence (Human):  NC_000017.

   

  • CGH (17q21.2):  Losses (%) -2.5  Gain (%)  6.3  Amplifications (%)  0.0
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 400 amino acids; 44106 Da
  • Catalytic activity:

  • Subcellular location: intracellular,cytoplasm,cytoskeleton,intermed filament

  • Protein domains

       

                          
  • Pathways and interactions (According to BioCarta, DIP)

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)